circRNA basic information
circBase ID: hsa_circ_0005075
Name: hsa_circ_EIF4G3
Synonym: -
Host Gene: EIF4G3
Genomic location(hg19): chr1:21377358-21415706:-
Genomic location(hg38): chr1:21050865-21089213:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005627
MONDO name: head and neck cancer
Disease details: head and neck cancer / HNC
Disease DO ID:
 11934
Disease MeSH ID:
 -
Disease NCIt ID:
 C4013
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancer tissues; normal tissues
Cell lines:

Detroit-562; WI-38
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: hsa_circ_0005075 is up-regulated in HNC cancer cells and reduced after irradiation; it is proposed as a potential biomarker candidate and is predicted to be associated with autophagic mechanisms.
Molecular mechanism: Functional prediction linked hsa_circ_0005075 to RNA catabolic process and autophagic mechanism.
Biological pathway or process:

autophagy (other); other pathway/process (other)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Bioinformatics Analysis
Clinical significance:

Potential biomarker for diagnosis, prognosis, or radiotherapy follow-up in HNCs.
Description:

hsa_circ_0005075 is markedly up-regulated in Detroit-562 HNC cells compared with WI-38 control cells and is significantly reduced after irradiation. The study suggests it may be a biomarker candidate for HNC diagnosis, prognosis, or radiotherapy monitoring, and KEGG-based prediction links it to autophagic mechanisms.
Confidence score:

0.329
Other information
Title:

Profiling of circRNA expressions in radiation-treated head and neck cancer cells and the potential role of circPVT1.

Journal: Archives of oral biology
Published: 2023
PubMed ID: 37027893
Study type:

combined biological and bioinformatics study
Data availability: TCGA; CPTAC; CircNET platform; Table S1
Code availability: -