| Expression pattern: |
UP |
| Associated gene: |
BIRC5 / baculoviral IAP repeat-containing 5 |
| Associated microRNA: |
miR-3622a-3p |
| Biological function: |
Promotes CRC progression, tumor growth, cell viability, proliferation, invasion, migration, and cell cycle progression; inhibits apoptosis; has potential diagnostic and therapeutic significance. |
| Molecular mechanism: |
circ_0050102 acts through a miRNA sponge/ceRNA mechanism by binding hsa-miR-3622a-3p and modulating the downstream target BIRC5. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); cell cycle (promotes); other pathway/process (promotes) |
| Detected method: |
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; FISH / smFISH; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High AUC value of 0.958 indicates diagnostic potential; circ_0050102 is proposed as a promising diagnostic marker, biomarker, therapeutic target, and upstream strategy to downregulate BIRC5. |
| Description: |
circ_0050102 is upregulated in CRC and shows diagnostic potential with an AUC of 0.958. Functionally, circ_0050102 promotes CRC cell viability, proliferation, invasion, migration, cell cycle progression, and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts through a circ_0050102/miR-3622a-3p/BIRC5 regulatory axis consistent with a miRNA sponge/ceRNA mechanism. |
| Confidence score: |
0.7955 |