circRNA basic information
circBase ID: -
Name: hsa_circ_CA12
Synonym: circCA12
Host Gene: CA12
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001187
MONDO name: urinary bladder cancer
Disease details: urinary bladder cancer
Disease DO ID:
 11054
Disease MeSH ID:
 -
Disease NCIt ID:
 C9334
Disease ICD11 ID:
 1244512758
Disease OMIM ID:
 109800
Species: Human
Species details: Homo sapiens
Tissue specimen:

UBC tissues; matched non-malignant tissues
Cell lines:

svhuc1; 5637; RT-112; RT112; BIU-87; BIU87
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: NRAS, KRAS, HRAS, Ago2
Associated microRNA: miR-1184
Biological function: promotes proliferation; promotes colony formation; promotes migration; promotes invasion; promotes metastasis; promotes tumor growth in vivo
Molecular mechanism: circCA12 sponges miR-1184 and thereby up-regulates RAS family genes (NRAS, KRAS, HRAS).
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; Clinical Sample Validation
Clinical significance:

-
Description:

circCA12 is up-regulated in bladder cancer tissues and cell lines and promotes malignant phenotypes including proliferation, invasion/migration, and metastasis. Mechanistically, circCA12 mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-1184, leading to upregulation of RAS family targets (KRAS/NRAS/HRAS) and promoting UBC progression.
Confidence score:

0.7979
Other information
Title:

CircCA12 Promotes Malignant Process via Sponging miR-1184 and Upregulating RAS Family in Bladder Cancer.

Journal: Frontiers in genetics
Published: 2021
PubMed ID: 34234808
Study type:

combined biological and clinical study
Data availability: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Code availability: -