| Expression pattern: |
UP |
| Associated gene: |
SOX5 |
| Associated microRNA: |
miR-590-5p |
| Biological function: |
CircWHSC1 functions as an oncogene in NSCLC; it promotes NSCLC cell proliferation, migration, invasion and tumor growth in vivo, while circWHSC1 knockdown suppresses these malignant properties. |
| Molecular mechanism: |
CircWHSC1 acts as a ceRNA/molecular sponge for miR-590-5p, relieving miR-590-5p-mediated repression of SOX5 and thereby increasing SOX5 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circWHSC1 may serve as a potential biomarker for diagnosis and prognosis of NSCLC; high circWHSC1 expression is associated with lower 5-year overall survival and poor prognosis. |
| Description: |
circWHSC1 is up-regulated in NSCLC tissues and cell lines and its high expression predicts poorer overall survival. Functionally, circWHSC1 promotes NSCLC proliferation, migration, invasion and xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-590-5p to increase SOX5 expression, forming a circWHSC1/miR-590-5p/SOX5 oncogenic axis. |
| Confidence score: |
0.7548 |