circRNA basic information
circBase ID: hsa_circ_0000497
Name: hsa_circ_SLAIN
Synonym: hsa_circ_000839
Host Gene: SLAIN
Genomic location(hg19): chr18:21644103-21649235:+
Genomic location(hg38): chr18:24064139-24069271:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: RECK, ZEB1, BTG2, SMAD3, SNAI2, FOXM1, NFKB1, SMAD7, E2F1, ATF3
Associated microRNA: hsa‐mir‐409‐3p, hsa‐mir‐590‐5p, hsa‐mir‐331‐3p, hsa‐mir‐654‐3p, hsa‐mir‐944, hsa‐mir‐1200
Biological function: tumor-suppressive role in breast cancer
Molecular mechanism: ceRNA network regulation (in silico)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Downregulated in BC tumors; hsa_circ_000839 expression level has a significant negative correlation with body mass index (BMI)
Description:

hsa_circ_000839 is significantly down-regulated in breast cancer tumor tissues compared with paired adjacent tissues, supporting a tumor-suppressive association in BC. The study computationally constructed a hsa_circ_000839-centered ceRNA network (circRNA-miRNA-mRNA), highlighting predicted interactions with multiple miRNAs (e.g., hsa-mir-409-3p, hsa-mir-590-5p) and cancer-relevant mRNAs (e.g., RECK, ZEB1, BTG2).
Confidence score:

0.348
Other information
Title:

Potential roles of hsa_circ_000839 and hsa_circ_0005986 in breast cancer.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 35098570
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -