| Expression pattern: |
UP |
| Associated gene: |
CRISP3, AGO2 |
| Associated microRNA: |
miR-607 |
| Biological function: |
promotes proliferation, migration, invasion, metastasis, tumorigenesis and Apatinib resistance in ESCC; knockdown increases apoptosis under Apatinib treatment |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0003823 sponges miR-607 to relieve inhibition of CRISP3, thereby promoting ESCC progression/metastasis and Apatinib resistance |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes); drug resistance (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; ISH (In Situ Hybridization); Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0003823 expression is associated with higher T stage, N stage and TNM stage, and shorter overall survival and progression-free survival; has diagnostic value distinguishing tumor from paracancerous tissues |
| Description: |
hsa_circ_0003823 (circCEP70) is up-regulated in ESCC and mainly localized in the cytoplasm. It functions as a ceRNA by sponging miR-607 to upregulate CRISP3, thereby promoting ESCC proliferation, invasion/migration/metastasis and increasing resistance to Apatinib; high expression correlates with advanced stage and worse survival. |
| Confidence score: |
0.8846 |