| Expression pattern: |
UP |
| Associated gene: |
PIK3CB |
| Associated microRNA: |
miR-532-3p |
| Biological function: |
promotes PDAC cell growth, proliferation, migration, invasion, xenograft tumor growth and lung metastasis; inhibits apoptosis |
| Molecular mechanism: |
circFGFR1 acts as a competing endogenous RNA by sponging miR-532-3p to upregulate PIK3CB expression, thereby promoting malignant progression of PDAC |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; ISH (In Situ Hybridization); FISH / smFISH; Clinical Sample Validation; IHC (Immunohistochemistry); Transfection; MTT; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model; H&E Staining; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high circFGFR1 expression correlated with lymph-node metastasis and higher TNM stages, indicated lower survival rate, and circFGFR1 might serve as a potential therapeutic target for PDAC |
| Description: |
circFGFR1 is up-regulated in PDAC tissues and cell lines, and high expression is associated with lymph-node metastasis, higher TNM stage, and poorer survival. Functionally, circFGFR1 promotes PDAC proliferation, migration, invasion, tumor growth, and lung metastasis while inhibiting apoptosis. Mechanistically, cytoplasmic circFGFR1 sponges miR-532-3p to increase PIK3CB expression and activate PI3K-related malignant processes. |
| Confidence score: |
0.8498 |