circRNA basic information
circBase ID: -
Name: hsa_circ_MGA
Synonym: circMGA
Host Gene: MGA
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021063
MONDO name: malignant colon neoplasm
Disease details: colon cancer
Disease DO ID:
 219
Disease MeSH ID:
 -
Disease NCIt ID:
 C9242
Disease ICD11 ID:
 1265576634
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

fresh-frozen tumor tissue / primary colon tumors
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: Presence is associated with reduced relapse risk and favorable disease-free survival.
Molecular mechanism: Not specified.
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Detection (presence) of circMGA is associated with favorable DFS; absence is significantly associated with relapse.
Description:

In stage I-II chemonaive colon cancer, presence of circMGA (vs absence) is associated with lower relapse and better disease-free survival. The work supports circMGA as a potential prognostic biomarker, but does not define a molecular mechanism.
Confidence score:

0.5121
Other information
Title:

Circular RNA in Chemonaive Lymph Node Negative Colon Cancer Patients.

Journal: Cancers
Published: 2021
PubMed ID: 33920880
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available on request from the corresponding author.
Code availability: -