| Expression pattern: |
UP |
| Associated gene: |
MAP2K7, ERK, p-ERK, p38MAPK, p-p38MAPK, METTL14 |
| Associated microRNA: |
miR-331-3p |
| Biological function: |
promotes proliferation and motility, inhibits apoptosis, and accelerates malignant phenotypes of NSCLC cells |
| Molecular mechanism: |
METTL14-mediated m6A modification increases circ_0060927 expression; circ_0060927 acts as a miRNA sponge for miR-331-3p, relieving repression of MAP2K7 and activating ERK/MAPK signaling |
| Biological pathway or process: |
ERK (promotes); MAPK (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); m6A modification (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
- |
| Description: |
circ_0060927 is up-regulated in NSCLC cell lines and promotes proliferation, migration/invasion, and reduces apoptosis. Mechanistically, METTL14-driven m6A methylation increases circ_0060927 levels, enabling it to sponge miR-331-3p, derepress MAP2K7, and activate the ERK/MAPK signaling cascade. |
| Confidence score: |
0.5992 |