| Expression pattern: |
DN |
| Associated gene: |
KANK1 |
| Associated microRNA: |
miR-589-5p |
| Biological function: |
inhibits proliferation, migration, invasion, tumor growth, and metastasis in gastric cancer |
| Molecular mechanism: |
ceRNA sponge of miR-589-5p to upregulate KANK1 |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; Sanger Sequencing; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
might be a novel promising biomarker in GC cells |
| Description: |
circCASP9 is down-regulated in gastric cancer tissues and cell lines and functions as a tumor suppressor. It sponges miR-589-5p to upregulate KANK1, thereby inhibiting proliferation, migration/invasion, tumor growth, and liver metastasis. |
| Confidence score: |
0.774 |