| Expression pattern: |
UP |
| Associated gene: |
SLC7A11 |
| Associated microRNA: |
miR-1276 |
| Biological function: |
Promotes proliferation, migration, EMT, tumor growth and 5-FU resistance; inhibits apoptosis and ferroptosis in gastric cancer cells. |
| Molecular mechanism: |
circTMEM87A acts as a ceRNA/sponge for miR-1276 to increase SLC7A11 expression, thereby promoting gastric cancer progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ferroptosis (inhibits); EMT (promotes); ceRNA regulation (promotes); chemoresistance (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circTMEM87A expression was significantly associated with differentiation, tumor size, TNM stage, and lymph node metastasis of GC patients; it may be a potential therapeutic target for GC. |
| Description: |
circTMEM87A is upregulated in gastric cancer tissues and cell lines. It promotes malignant GC phenotypes by sponging miR-1276 and increasing SLC7A11 expression, leading to enhanced proliferation, migration, EMT and tumor growth, while suppressing apoptosis and ferroptosis. Its expression is associated with clinicopathologic features including differentiation, tumor size, TNM stage and lymph node metastasis. |
| Confidence score: |
0.8299 |