circRNA basic information
circBase ID: hsa_circ_0009910
Name: hsa_circ_MFN2
Synonym: circ_0009910
Host Gene: MFN2
Genomic location(hg19): chr1:12049221-12052747:+
Genomic location(hg38): chr1:11989164-11992690:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent nontumor tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: UBE2L3
Associated microRNA: miR-1261
Biological function: Participates in the pathogenesis of HCC as a ceRNA, acting as a sponge of miR-1261 to regulate UBE2L3.
Molecular mechanism: ceRNA/miRNA sponge mechanism (hsa_circ_0009910 sponges miR-1261, affecting UBE2L3 expression).
Biological pathway or process:

ceRNA regulation (promotes); ubiquitination (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

This study identified hsa_circ_0009910 as up-regulated in HCC tissues and proposed it functions as a ceRNA by sponging miR-1261 to increase the expression of UBE2L3. The hsa_circ_0009910-miR-1261-UBE2L3 axis was supported by integrated bioinformatics and RT-qPCR validation in paired clinical samples.
Confidence score:

0.5135
Other information
Title:

Bioinformatic Analysis of Circular RNA-Associated ceRNA Network Associated with Hepatocellular Carcinoma.

Journal: BioMed research international
Published: 2019
PubMed ID: 31886256
Study type:

combined biological and clinical study
Data availability: GSE78520; GSE97332; GSE94508; GSE64632
Code availability: -