| Expression pattern: |
UP |
| Associated gene: |
ACTN4, AGO2, PGAM5 |
| Associated microRNA: |
miR-876-3p |
| Biological function: |
Promotes tamoxifen resistance, tumour growth, cell survival, proliferation, migration and invasion, and inhibits apoptosis in breast cancer cells. |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0097922 acts as a miR-876-3p sponge to regulate ACTN4 expression, thereby promoting malignant behaviour and tamoxifen resistance. |
| Biological pathway or process: |
ceRNA regulation (promotes); drug resistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0097922 expression was associated with TNM stage and may be a promising therapeutic target/preclinical basis for drug-resistant breast cancer patients. |
| Description: |
hsa_circ_0097922 is up-regulated in breast cancer tissues and tamoxifen-resistant breast cancer cells. It promotes malignant phenotypes and tamoxifen resistance by sponging miR-876-3p and increasing ACTN4 expression, while its knockdown sensitizes resistant cells and xenograft tumors to tamoxifen. |
| Confidence score: |
0.8572 |