circRNA basic information
circBase ID: hsa_circ_0005694
Name: hsa_circ_AHRR
Synonym: -
Host Gene: AHRR
Genomic location(hg19): chr5:353844-376831:+
Genomic location(hg38): chr5:353729-376716:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MG63
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: CCND2, BCL2, BAX
Associated microRNA: miR-150-5p
Biological function: associated with 5-FU-induced inhibition of proliferation and apoptosis-related processes in osteosarcoma cells
Molecular mechanism: predicted circRNA-miRNA-mRNA interaction network (ceRNA-like)
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; RT-qPCR; divergent primers PCR; Bioinformatics Analysis; Western Blot
Clinical significance:

-
Description:

hsa_circ_0005694 is down-regulated in MG63 osteosarcoma cells after 5-FU treatment and was analyzed within predicted circRNA-miRNA-mRNA networks linked to proliferation and apoptosis. It was predicted to bind miR-150-5p, and downstream mRNA/protein changes were examined by qPCR/WB in the study’s network validation.
Confidence score:

0.5608
Other information
Title:

The Analysis of Differentially Expressed circRNAs Under the Antiproliferative Effect From 5-Fluorouracil on Osteosarcoma Cells.

Journal: Technology in cancer research & treatment
Published: 2020
PubMed ID: 33308021
Study type:

biological research
Data availability: Supplemental material for this article is available online; Table S1; Table S2
Code availability: -