circRNA basic information
circBase ID: hsa_circ_0001060
Name: hsa_circ_UXS1
Synonym: circ_0001060
Host Gene: UXS1
Genomic location(hg19): chr2:106774513-106782539:-
Genomic location(hg38): chr2:106158057-106166083:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OS tumor tissues; adjacent tissues; tissue samples
Cell lines:

Saos-2; 143B; MG-63; HOS; U2OS; hFOB1.19; Saos2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TRIM21, MAP3K5, PRKX
Associated microRNA: miR-203a-5p, miR-208b-5p, hsa-miR-627-3p, hsa-miR-140-5p, hsa-miR-29a-5p, hsa-miR-4762-3p, hsa-miR-5582-3p, hsa-miR-6769a-5p, hsa-miR-6873-3p
Biological function: promotes OS progression, proliferation, migration and invasion; inhibits apoptosis and G0/G1 phase arrest
Molecular mechanism: circ_0001060 may act as a miRNA sponge and participate in circRNA-miRNA-mRNA regulatory modules including circ_0001060-miR-203a-5p-TRIM21, circ_0001060-miR-208b-5p-MAP3K5, and circ_0001060-miR-203a-5p-PRKX
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes); metastasis (promotes); other pathway/process (other)
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

high expression is associated with late clinical stage, larger tumor volume, higher frequency of metastasis, poor prognosis, poorer overall survival, and potential diagnostic value in OS
Description:

circ_0001060 is up-regulated in osteosarcoma and high expression is associated with metastasis, larger tumor size, poor overall survival, and diagnostic potential. Functionally, circ_0001060 promotes OS cell proliferation, migration, invasion, and cell cycle progression while suppressing apoptosis. Mechanistically, it is mainly cytoplasmic and may function as a miRNA sponge within circRNA-miRNA-mRNA axes involving miR-203a-5p/TRIM21, miR-208b-5p/MAP3K5, and miR-203a-5p/PRKX.
Confidence score:

0.8308
Other information
Title:

Circ_0001060 Upregulates and Encourages Progression in Osteosarcoma.

Journal: DNA and cell biology
Published: 2023
PubMed ID: 36580535
Study type:

combined biological and clinical study
Data availability: Supplementary Table S1
Code availability: -