| Expression pattern: |
UP |
| Associated gene: |
ZEB1, Snail, Ago2 |
| Associated microRNA: |
miR-153-3p, miR-8084 |
| Biological function: |
promotes OS cell migration, invasion, EMT, lung metastasis, and metastatic progression |
| Molecular mechanism: |
circMGEA5 acts as a ceRNA sponging miR-153-3p and miR-8084 to increase ZEB1 and Snail expression; ZEB1 and Snail bind the circMGEA5 promoter and activate circMGEA5 transcription, forming a positive feedback loop |
| Biological pathway or process: |
ceRNA regulation (promotes); EMT (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; Western Blot; ChIP / ChIP-seq; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circMGEA5 was associated with shorter overall and disease-free survival time and may be a promising biomarker for predicting OS metastasis and prognosis |
| Description: |
circMGEA5 is up-regulated in metastatic osteosarcoma tissues and high expression predicts poor overall and disease-free survival. It promotes OS migration, invasion, EMT, and lung metastasis by sponging miR-153-3p and miR-8084 to increase ZEB1 and Snail, while ZEB1 and Snail transcriptionally activate circMGEA5 to form a positive feedback loop. |
| Confidence score: |
0.8633 |