| Expression pattern: |
UP |
| Associated gene: |
FOSL2 |
| Associated microRNA: |
miR-638 |
| Biological function: |
promotes proliferation, migration, invasion and metastasis; promotes tumor growth; induces cell cycle progression |
| Molecular mechanism: |
ceRNA sponge of miR-638 to upregulate FOSL2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
High hsa_circ_0001869 expression predicted poor overall survival in NSCLC. |
| Description: |
hsa_circ_0001869 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. It promotes NSCLC proliferation, migration, invasion and in vivo tumor growth by sponging miR-638 and thereby enhancing FOSL2 expression, and high expression is associated with poor overall survival. |
| Confidence score: |
0.7631 |