| Expression pattern: |
UP |
| Associated gene: |
PSAT1 |
| Associated microRNA: |
miR-5195-3p |
| Biological function: |
promotes NSCLC cell proliferation, migration, invasion, EMT, and tumor growth |
| Molecular mechanism: |
exosomal circERBB2IP functions as a miR-5195-3p sponge to upregulate PSAT1 (ceRNA axis) |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; MTT; EdU Staining; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
Upregulation of circERBB2IP was observed in exosomes derived from NSCLC patient's serum and circERBB2IP might be a potential diagnostic biomarker for NSCLC. |
| Description: |
Exosomal circERBB2IP (hsa_circ_0001492, from ERBB2IP) is up-regulated in NSCLC serum exosomes and NSCLC cells and shows diagnostic potential (AUC reported). Functionally, circERBB2IP promotes NSCLC proliferation, migration, invasion, EMT, and xenograft tumor growth by sponging miR-5195-3p to increase PSAT1 expression. |
| Confidence score: |
0.7821 |