| Expression pattern: |
UP |
| Associated gene: |
circPDIA4, DHX9 |
| Associated microRNA: |
- |
| Biological function: |
Acts as an oncogenic circRNA that promotes invasive activity of gastric cancer cells downstream of circPDIA4/DHX9-dependent circRNA biogenesis. |
| Molecular mechanism: |
circPDIA4-mediated upregulation of circ_0001610 depends on DHX9 protein; silencing circ_0001610 rescues circPDIA4-driven invasion. |
| Biological pathway or process: |
invasion (promotes); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Clinical Sample Validation; Transfection; Transwell Assay; Bioinformatics Analysis |
| Clinical significance: |
circ_0001610 is up-regulated in gastric cancer specimens and positively correlated with circPDIA4 expression. |
| Description: |
hsa_circ_0001610/circ_0001610 is up-regulated in gastric cancer tissues and is induced by circPDIA4 through a DHX9-dependent mechanism. Functional rescue experiments indicate that circ_0001610 contributes to circPDIA4-driven invasive activity in gastric cancer cells. |
| Confidence score: |
0.6102 |