| Expression pattern: |
DN |
| Associated gene: |
EIF4EBP2, eIF4E, phosphorylated eIF4E, ODC1, VEGFA, FGF2, Ago2 |
| Associated microRNA: |
miR-1252-5p |
| Biological function: |
acts as a tumor suppressor; inhibits cell viability, proliferation, migration, invasion and tumor growth; promotes apoptosis |
| Molecular mechanism: |
circ_0000190 acts as a ceRNA sponge for miR-1252-5p to regulate EIF4EBP2, thereby increasing EIF4EBP2 binding to eIF4E and preventing eIF4E activity |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Transwell Assay; In Vivo Animal Model; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; RNA Pull-Down; Bioinformatics Analysis |
| Clinical significance: |
could be treated as a promising biomarker for the diagnosis of CC |
| Description: |
circ_0000190 is down-regulated in cervical cancer cells and functions as a tumor suppressor. Its overexpression inhibits proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0000190 sponges miR-1252-5p to up-regulate EIF4EBP2, which suppresses eIF4E activity. |
| Confidence score: |
0.6873 |