| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-599 |
| Biological function: |
Independent risk factor and potential early diagnostic biomarker for prehypertension and hypertension; may act as a miRNA sponge and may be involved in cardiac injury during hypertension progression. |
| Molecular mechanism: |
Predicted miRNA sponge mechanism; circRNA-miRNA network with GO and KEGG enrichment suggesting involvement in cell aging/cellular senescence, longevity regulating pathway, relaxin signaling pathway, and autophagy-related processes. |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (other); proliferation (other); migration (other); angiogenesis (other); autophagy (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Upregulated circ_0000284 was an independent risk factor for prehypertension and hypertension and showed diagnostic value for hypertension and prehypertension. |
| Description: |
This study found that circ_0000284 is upregulated in peripheral blood during progression from normal blood pressure to prehypertension and hypertension. Its high expression is an independent risk factor and a potential diagnostic biomarker, and bioinformatics analyses suggest it may function as a miRNA sponge involved in hypertension-related biological processes. |
| Confidence score: |
0.459 |