circRNA basic information
circBase ID: -
Name: hsa_circ_ARHGAP5
Synonym: circARHGAP5
Host Gene: ARHGAP5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent tissues
Cell lines:

SMMC-7721
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: G3BP1, G3BP2
Associated microRNA: -
Biological function: associated with stress granule localization/enrichment (SG-enriched circRNA) and presumed to be related to SG formation
Molecular mechanism: enrichment in stress granules associated with higher binding ability to SG-related RBPs
Biological pathway or process:

other pathway/process (other)
Detected method:
S
Validation methods:

FISH / smFISH; IF (Immunofluorescence); RNA-seq
Clinical significance:

-
Description:

circARHGAP5 is experimentally validated to localize in cytoplasmic stress granules in SMMC-7721 cells by RNA FISH and immunofluorescence. The work supports an SG-related circRNA/RBP association but does not provide circARHGAP5 expression direction in HCC or prognostic/clinical associations.
Confidence score:

0.3213
Other information
Title:

Screening Linear and Circular RNA Transcripts from Stress Granules.

Journal: Genomics, proteomics & bioinformatics
Published: 2023
PubMed ID: 35085777
Study type:

biological research
Data availability: GSA-Human: HRA001512; https://ngdc.cncb.ac.cn/gsa-human/
Code availability: -