| Expression pattern: |
DN |
| Associated gene: |
FXR1, PRKCI, GSK3beta, AP-1, Snail |
| Associated microRNA: |
- |
| Biological function: |
Inhibits proliferation, invasion, and cisplatin (DDP) resistance in NSCLC cells. |
| Molecular mechanism: |
circ_0000079 binds/decoys the RNA-binding protein FXR1, interrupting FXR1/PRKCI complex formation and reducing downstream phosphorylation of GSK3beta and AP-1, thereby decreasing Snail expression. |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); EMT (inhibits); drug resistance (inhibits); apoptosis (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; Western Blot; Transfection; CCK8; Transwell Assay; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circ_0000079 levels were significantly associated with poor overall survival of NSCLC patients. |
| Description: |
circ_0000079 (hsa_circ_0000079, from USP1) is down-regulated in NSCLC, particularly in cisplatin-resistant cases, and low expression is associated with worse overall survival. Functionally, circ_0000079 suppresses proliferation, invasion, and cisplatin resistance by binding/decoying FXR1, disrupting the FXR1/PRKCI complex and reducing downstream signaling that supports EMT and drug resistance. |
| Confidence score: |
0.841 |