circRNA basic information
circBase ID: hsa_circ_0001649
Name: hsa_circ_SHPRH
Synonym: -
Host Gene: SHPRH
Genomic location(hg19): chr6:146209155-146216113:-
Genomic location(hg38): chr6:145888019-145894977:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma / OSCC
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; tumor tissues; adjacent normal tissues
Cell lines:

OECM1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Plasma biomarker associated with recurrence risk and poor prognosis; decreased plasma level correlates with early recurrence and reduced disease-free survival.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Survival Analysis; Cohort Study
Clinical significance:

Decreased plasma hsa_circ_0001649 is associated with OSCC recurrence and poor prognosis and correlates with shorter recurrence interval and worse disease-free survival.
Description:

hsa_circ_0001649 is decreased in OSCC patient plasma and low levels are associated with recurrence, shorter recurrence interval, and poorer survival outcomes, supporting its use as a prognostic plasma biomarker.
Confidence score:

0.6656
Other information
Title:

Identification of plasma hsa_circ_0000190 and 0001649 as biomarkers for predicting the recurrence and treatment response of patients with oral squamous cell carcinoma.

Journal: Journal of the Chinese Medical Association : JCMA
Published: 2022
PubMed ID: 35125403
Study type:

combined biological and clinical study
Data availability: http://links.lww.com/JCMA/A132
Code availability: -