| Expression pattern: |
UP |
| Associated gene: |
SPIN1 / spindlin1 |
| Associated microRNA: |
miR-644a |
| Biological function: |
Hsa_circ_0007380 promotes esophagus cancer cell proliferation, cell cycle progression, tumor growth and radioresistance, while inhibiting apoptosis; its knockdown suppresses growth and enhances radiosensitivity in vitro and in vivo. |
| Molecular mechanism: |
Hsa_circ_0007380 functions as a competing endogenous RNA that sponges miR-644a, thereby relieving miR-644a-mediated suppression of SPIN1. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); radioresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); RNA Pull-Down; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Potential therapeutic target for esophagus cancer combined treatment. |
| Description: |
Hsa_circ_0007380 is up-regulated in esophagus cancer tissues and cell lines. It acts as an oncogenic circRNA that promotes proliferation, tumor growth and radioresistance while inhibiting apoptosis, mainly through the hsa_circ_0007380/miR-644a/SPIN1 ceRNA axis. Silencing hsa_circ_0007380 enhances radiosensitivity, suggesting therapeutic potential in combined treatment for esophagus cancer. |
| Confidence score: |
0.8439 |