| Expression pattern: |
UP |
| Associated gene: |
CXCR4 |
| Associated microRNA: |
miR-373-3p |
| Biological function: |
circ_0001721 aggravates IL-1beta-induced chondrocyte injury by promoting chondrocyte apoptosis, extracellular matrix degradation and inflammation, while suppressing proliferation; circ_0001721 knockdown alleviates these injury phenotypes. |
| Molecular mechanism: |
circ_0001721 functions as a miR-373-3p sponge to upregulate CXCR4, thereby aggravating IL-1beta-induced chondrocyte injury. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); apoptosis (promotes); inflammation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Annexin V/PI Flow Cytometry; ELISA; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0001721 is highly expressed in OA patients and might be a potential therapeutic target for OA. |
| Description: |
In this study, circ_0001721 was up-regulated in cartilage tissues from OA patients and in IL-1beta-induced human chondrocytes. Functional experiments showed that circ_0001721 knockdown relieved IL-1beta-induced chondrocyte injury by promoting proliferation and reducing apoptosis, ECM degradation and inflammation. Mechanistically, circ_0001721 acted as a sponge for miR-373-3p to upregulate CXCR4, supporting its potential as a therapeutic target for OA. |
| Confidence score: |
0.8417 |