circRNA basic information
circBase ID: -
Name: hsa_circ_MDM2
Synonym: circ_MDM2_000139
Host Gene: MDM2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

NCL-H1299; A549; HCC-827
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: POLR2A
Associated microRNA: let-7 family members
Biological function: Might be involved in the function/mechanism of XAV939 treatment in NSCLC.
Molecular mechanism: Predicted miRNA-circRNA regulatory interaction with let-7 family members; predicted transcriptional regulation by POLR2A.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_MDM2_000139 is a disease-associated DE-circRNA in NSCLC cells and is downregulated after XAV939 treatment. The study predicts it interacts with let-7 family miRNAs and is targeted by the transcription factor POLR2A, suggesting involvement in XAV939-related regulatory mechanisms.
Confidence score:

0.2465
Other information
Title:

Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer.

Journal: Canadian respiratory journal
Published: 2019
PubMed ID: 31885751
Study type:

biological research
Data availability: SRP136747
Code availability: -