circRNA basic information
circBase ID: hsa_circ_0000615
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr15:64791491-64792365:+
Genomic location(hg38): chr15:64499292-64500166:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

Hep G2; Huh 7; Hep G2/sorafenib; Huh 7/sorafenib
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with sorafenib resistance and poorer survival outcomes in HCC; proposed as a driver of chemoresistance.
Molecular mechanism: -
Biological pathway or process:

chemoresistance (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Cohort Study
Clinical significance:

Serum hsa_circ_0000615 is upregulated in chemoresistant HCC and is an independent predictor of OS/PFS; ROC AUC=0.9238 to differentiate HCC patients and healthy controls; high expression associated with shorter OS.
Description:

Serum hsa_circ_0000615 is up-regulated in HCC, especially in sorafenib-resistant patients, and higher levels correlate with advanced stage and shorter survival. It shows diagnostic/prognostic utility (ROC) and is proposed as a driver/biomarker of sorafenib resistance.
Confidence score:

0.4992
Other information
Title:

Serum hsa_circ_0000615 is a prognostic biomarker of sorafenib resistance in hepatocellular carcinoma.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 36268976
Study type:

combined biological and clinical study
Data availability: -
Code availability: -