| Expression pattern: |
UP |
| Associated gene: |
USP7, HK2, AGO2 |
| Associated microRNA: |
miR-125a-5p |
| Biological function: |
promotes proliferation and aerobic glycolysis; inhibits apoptosis; promotes GC progression |
| Molecular mechanism: |
ceRNA mechanism: circRPS19 sponges miR-125a-5p to upregulate USP7, which deubiquitinates and stabilizes HK2 protein to enhance aerobic glycolysis |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes); ubiquitination (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; CCK8; EdU Staining; TUNEL; Annexin V/PI Flow Cytometry; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Co-IP; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot |
| Clinical significance: |
may be a novel therapeutic target for GC |
| Description: |
circRPS19 is upregulated in gastric cancer cells and promotes tumor cell proliferation and aerobic glycolysis while inhibiting apoptosis. Mechanistically, it sponges miR-125a-5p to increase USP7, which deubiquitinates and stabilizes HK2 protein, enhancing glycolysis and GC progression in vitro and in vivo. |
| Confidence score: |
0.8546 |