| Expression pattern: |
UP |
| Associated gene: |
serine/arginine-rich splicing Factor 1 (SRSF1), PARK2, vascular endothelial growth factor-A (VEGFA), C-myc, cyclin D1, Fzd-2, GSK-3beta, beta-catenin |
| Associated microRNA: |
- |
| Biological function: |
circCDR1as promotes PM2.5-stimulated lung cancer cell viability, proliferation, colony formation, migration, invasion, tumour growth and metastasis, and inhibits apoptosis. |
| Molecular mechanism: |
circCDR1as binds SRSF1, prevents PARK2-mediated SRSF1 ubiquitination and degradation, regulates VEGFA mRNA splicing through SRSF1, and activates Wnt/beta-catenin signaling with increased downstream C-myc and CyclinD1. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); angiogenesis (promotes); ubiquitination (inhibits); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Actinomycin D / DRB Stability Assay; FISH / smFISH; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; RNA Pull-Down; Western Blot; Co-IP; IF (Immunofluorescence); IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
potential biomarker of PM2.5-induced lung cancer progression |
| Description: |
circCDR1as is upregulated in PM2.5-exposed lung cancer cells and promotes PM2.5-induced malignant progression. Mechanistically, it binds SRSF1, inhibits PARK2-mediated ubiquitination and degradation of SRSF1, regulates VEGFA mRNA splicing, and activates Wnt/beta-catenin signaling to enhance malignant behavior and suppress apoptosis. |
| Confidence score: |
0.8207 |