circRNA basic information
circBase ID: hsa_circ_0006948
Name: hsa_circ_FNDC3B
Synonym: circ_0006948
Host Gene: FNDC3B
Genomic location(hg19): chr3:171830241-171944737:+
Genomic location(hg38): chr3:172112451-172226947:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005580
MONDO name: esophageal squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Disease DO ID:
 3748
Disease MeSH ID:
 C562729; D000077277
Disease NCIt ID:
 C4024
Disease ICD11 ID:
 1417891145
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ESCC tissues; adjacent normal tissues
Cell lines:

TE-1; KYSE30; TE-7; TE-13; KYSE150; HEEC; HEK-293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HMGA2, AGO2
Associated microRNA: miR-490-3p
Biological function: promotes proliferation, migration and invasion; induces EMT; promotes tumor growth in vivo
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-490-3p to upregulate HMGA2, thereby inducing EMT.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

High hsa_circ_0006948 levels were positively associated with lymphatic metastasis and poor prognosis; hsa_circ_0006948 was an independent prognostic factor for ESCC prognosis; diagnostic value AUC 0.85.
Description:

hsa_circ_0006948 is up-regulated in ESCC tissues/cell lines and promotes proliferation, migration, invasion, EMT, and xenograft tumor growth. Mechanistically, it acts as a miR-490-3p sponge to increase HMGA2 expression, contributing to EMT and aggressive progression, and high expression predicts poor overall survival.
Confidence score:

0.8715
Other information
Title:

Hsa_circ_0006948 enhances cancer progression and epithelial-mesenchymal transition through the miR-490-3p/HMGA2 axis in esophageal squamous cell carcinoma.

Journal: Aging
Published: 2019
PubMed ID: 31881015
Study type:

combined biological and clinical study
Data availability: GSE131969
Code availability: -