| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential biomarker for postmortem diagnosis of AMI; can distinguish AMI and normal control cases, including early-MI cases. |
| Molecular mechanism: |
No disease mechanism was explored; the study focused on forensic diagnostic application and circRNA stability due to loop structure. |
| Biological pathway or process: |
not specified (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Clinical Sample Validation; In Vivo Animal Model; H&E Staining; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circLRBA is a potential biomarker for postmortem diagnosis of AMI, with ROC AUC values of 0.862 for MI, 0.767 for early-MI, and 0.817 for MI + early-MI. |
| Description: |
circLRBA was screened from GEO AMI circRNA expression data and validated as a stable circular RNA. Its expression decreased in mouse AMI models and in human forensic MI and early-MI autopsy cases, supporting its value as a postmortem diagnostic biomarker for AMI. |
| Confidence score: |
0.7241 |