| Expression pattern: |
DN |
| Associated gene: |
FAM13B (linear form) |
| Associated microRNA: |
- |
| Biological function: |
Potential biomarker and implicated in PD pathogenesis; signal remains significant after adjusting for linear transcript counts (both linear and circular forms significant). |
| Molecular mechanism: |
Predicted miRNA targeting (in-silico) with circRNA-miRNA correlations; downstream pathway enrichment via miRNAs. |
| Biological pathway or process: |
Hippo/YAP (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
Differentially accumulated in PD blood; both circular and linear FAM13B remain significant when modeled together, supporting a robust association. |
| Description: |
circFAM13B is down-regulated in PD blood and remains significantly associated with PD even after jointly modeling its host gene’s linear transcript, suggesting an association beyond simple host-gene expression changes. It is among the study’s five high-confidence blood circRNAs and was further explored via predicted miRNA targets and pathway enrichment. |
| Confidence score: |
0.348 |