| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Inhibits ICC cell proliferation and increases chemotherapy sensitivity to cisplatin and gemcitabine. |
| Molecular mechanism: |
Not specified (mechanism not included in this study). |
| Biological pathway or process: |
proliferation (inhibits); chemoresistance (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; CCK8; Survival Analysis |
| Clinical significance: |
High circ-SMARCA5 expression is associated with favorable clinicopathological features and longer overall survival; potential prognostic biomarker for ICC. |
| Description: |
circ-SMARCA5 is down-regulated in ICC tumor tissue and higher tumor expression predicts longer overall survival and more favorable clinical features. Functionally, circ-SMARCA5 overexpression suppresses ICC cell proliferation and increases sensitivity to cisplatin and gemcitabine, although the detailed molecular mechanism was not determined in this study. |
| Confidence score: |
0.6524 |