circRNA basic information
circBase ID: hsa_circ_0020397
Name: hsa_circ_DOCK1
Synonym: -
Host Gene: DOCK1
Genomic location(hg19): chr10:128768965-128926028:+
Genomic location(hg38): chr10:126970701-127127764:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005086
MONDO name: renal cell carcinoma
Disease details: renal cell carcinoma / RCC
Disease DO ID:
 4450
Disease MeSH ID:
 D002292
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

RCC tissues; adjacent normal tissues; tumor samples; adjacent non-cancerous tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: CASP8, CCND1, CYCS
Associated microRNA: hsa-miR-150, hsa-miR-34a, hsa-miR-494, hsa-miR-182
Biological function: Potential tumor-suppressive role in RCC; downregulation may increase RCC metastasis; proposed involvement in ceRNA-mediated regulation of hub genes.
Molecular mechanism: Predicted ceRNA mechanism involving sponging of hsa-miR-150, hsa-miR-34a, hsa-miR-494 and hsa-miR-182 to regulate CASP8, CCND1 and CYCS.
Biological pathway or process:

ceRNA regulation (other); metastasis (inhibits); apoptosis (other); cell cycle (other)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

hsa_circ_0020397 had significantly lower expression in RCC patients with a history of kidney disease.
Description:

hsa_circ_0020397 was significantly downregulated in RCC tissues and in ccRCC samples. The study predicts that it may act as a ceRNA in RCC, particularly through hsa-miR-150/CASP8 and hsa-miR-34a/CYCS-related axes, and its downregulation may contribute to RCC metastasis.
Confidence score:

0.4685
Other information
Title:

Expression analysis of hsa_circ_0020397, hsa_circ_0005986, hsa_circ_0003028, and hsa_circ_0006990 in renal cell carcinoma.

Journal: Experimental and molecular pathology
Published: 2023
PubMed ID: 36496205
Study type:

combined biological, clinical and bioinformatics study
Data availability: GSE781; GSE6344; GSE14994; GSE16441; GSE17816; GSE17818; GSE17895; GSE26574; GSE36895; GSE40435; GSE40914; GSE46699; GSE53000; GSE53757; GSE68417; GSE71963; GSE55138; GSE41282; supplementary materials; data available on request
Code availability: -