| Expression pattern: |
UP |
| Associated gene: |
MYL6B |
| Associated microRNA: |
miR-653-5p |
| Biological function: |
promotes proliferation, migration, invasion, metastasis, EMT, and tumor growth in NSCLC |
| Molecular mechanism: |
ceRNA mechanism: circ_0114866 sponges miR-653-5p to increase MYL6B expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circ_0114866 may serve as a biomarker for NSCLC |
| Description: |
circ_0114866 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes NSCLC malignant phenotypes (proliferation, migration/invasion, EMT, and xenograft tumor growth) by acting as a ceRNA that sponges miR-653-5p to increase MYL6B expression. |
| Confidence score: |
0.7859 |