| Expression pattern: |
DN |
| Associated gene: |
APOA1 |
| Associated microRNA: |
miR-520 h |
| Biological function: |
inhibits osteosarcoma cell proliferation and migration/invasion; promotes apoptosis; suppresses tumor growth in vivo |
| Molecular mechanism: |
ceRNA (miRNA sponge): circ_0088212 sponges miR-520 h, relieving miR-520 h-mediated repression of APOA1 |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; In Vivo Animal Model; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot |
| Clinical significance: |
may function as a diagnostic and prognostic biomarker or therapeutic target for osteosarcoma |
| Description: |
circ_0088212 is down-regulated in osteosarcoma tissues and cell lines. Its overexpression suppresses proliferation and invasion/migration and promotes apoptosis, including reduced tumor growth in a SW1353 xenograft model, mainly by sponging miR-520 h and thereby relieving repression of APOA1. |
| Confidence score: |
0.7914 |