circRNA basic information
circBase ID: -
Name: hsa_circ_N4BP2L2
Synonym: circ-N4BP2L2
Host Gene: N4BP2L2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018932
MONDO name: cirrhotic cardiomyopathy
Disease details: cirrhotic cardiomyopathy / CCM
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 1268082489
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

venous blood samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Significantly downregulated after liver transplantation compared with before liver transplantation in CCM patients, suggesting association with CCM-related circRNA expression changes.
Molecular mechanism: Not experimentally defined for circ-N4BP2L2.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circ-N4BP2L2 was significantly downregulated after liver transplantation in CCM patients, consistent with RNA sequencing and qRT-PCR results. The study supports its differential expression association with CCM before and after liver transplantation, but does not provide a specific mechanistic validation for this circRNA.
Confidence score:

0.4032
Other information
Title:

Comprehensive evaluation of circRNAs in cirrhotic cardiomyopathy before and after liver transplantation.

Journal: International immunopharmacology
Published: 2023
PubMed ID: 36462338
Study type:

combined bioinformatics and clinical study
Data availability: -
Code availability: -