| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
circRNA 100876 is up-regulated in NSCLC tissues and is associated with lymph node metastasis, advanced tumor staging, and shorter overall survival; it may be involved in NSCLC carcinogenesis, tumor progression and metastasis. |
| Molecular mechanism: |
Not experimentally elucidated in this study; the authors speculated that circRNA 100876 might regulate tumor-related gene expression as miRNA sponges in NSCLC. |
| Biological pathway or process: |
metastasis (promotes); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
High circRNA 100876 expression is associated with lymph node metastasis, advanced tumor staging, and poor prognosis in NSCLC; it may serve as a potential prognostic biomarker and therapeutic target. |
| Description: |
This study found that circRNA 100876 is significantly up-regulated in NSCLC tumor tissues compared with adjacent nontumorous tissues. Higher expression correlates with lymph node metastasis, advanced tumor stage, and shorter overall survival, supporting its potential value as a poor-prognosis biomarker in NSCLC. The mechanistic role was not experimentally defined in this paper. |
| Confidence score: |
0.4758 |