circRNA basic information
circBase ID: hsa_circ_0001836
Name: hsa_circ_RFX3
Synonym: circRFX3 / hsa_circRFX3_003
Host Gene: RFX3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: Colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood; peripheral blood lymphocytes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-587
Biological function: May act as a miRNA sponge (miR-587) in CRC; proposed role in CRC pathophysiology and potential diagnostic biomarker in blood.
Molecular mechanism: ceRNA/miRNA sponge mechanism via circRFX3 binding to miR-587 (predicted by circinteractome; correlation observed).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

CircRFX3 may be used as a predictive biomarker for distinguishing CRC from controls (AUC 0.66).
Description:

circRFX3 is down-regulated in peripheral blood lymphocytes/blood of CRC patients and negatively correlates with miR-587. The study suggests circRFX3 may act as a sponge for miR-587 (supported by circinteractome prediction) and has potential diagnostic value for CRC (AUC 0.66).
Confidence score:

0.459
Other information
Title:

Expression patterns of circRFX3 and miR-587 in colorectal cancer patients.

Journal: Molecular biology research communications
Published: 2025
PubMed ID: 40321703
Study type:

clinical study
Data availability: -
Code availability: -