circRNA basic information
circBase ID: hsa_circ_0115476
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004925
MONDO name: chronic dacryocystitis
Disease details: chronic dacryocystitis
Disease DO ID:
 9937
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 617640909
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lacrimal sac samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: CD4
Associated microRNA: hsa-miR-7152-3p
Biological function: may regulate Th1 and Th2 cell differentiation and participate in CD4+ T cell infiltration
Molecular mechanism: ceRNA mechanism (circRNA-miRNA-mRNA)
Biological pathway or process:

immune regulation (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0115476 (also written as has_circ_0115476) is down-regulated in chronic dacryocystitis lacrimal sac tissue and was validated by RT-qPCR. Bioinformatic ceRNA network analysis suggests it may sponge hsa-miR-7152-3p to regulate CD4, potentially affecting CD4+ T-cell infiltration/Th1-Th2-related immune processes in chronic dacryocystitis.
Confidence score:

0.4032
Other information
Title:

Differently Expressed Circular RNAs in Lacrimal Sacs From Patients With Chronic Dacryocystitis.

Journal: Frontiers in genetics
Published: 2022
PubMed ID: 35295950
Study type:

combined biological and clinical study
Data availability: https://www.frontiersin.org/articles/10.3389/fgene.2022.834111/full#supplementary-material
Code availability: -