circRNA basic information
circBase ID: hsa_circ_0007919
Name: hsa_circ_ABR
Synonym: circ_0007919
Host Gene: ABR
Genomic location(hg19): chr17:953289-1003975:-
Genomic location(hg38): chr17:1050049-1100735:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; para-cancerous tissues; para-tumor tissues; normal colonic tissues
Cell lines:

NCM460; HT29; SW480; HCT-116; LoVo; HEK-293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: TET1 mRNA, TET1
Associated microRNA: miR-942-5p
Biological function: circ_0007919 inhibits CRC cell growth, proliferation and migration, and acts as a tumor suppressor in colorectal cancer.
Molecular mechanism: circ_0007919 functions as a cytoplasmic ceRNA that sponges miR-942-5p, thereby increasing TET1 expression and probably regulating epigenetics in CRC cells.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; BrdU; Transwell Assay; Wound Healing Assay; Western Blot; Survival Analysis
Clinical significance:

Low circ_0007919 expression was associated with shorter overall survival, TNM stage and histopathological grade in CRC patients.
Description:

circ_0007919 is down-regulated in colorectal cancer tissues and cell lines, and its low expression is associated with shorter overall survival. Functionally, circ_0007919 suppresses CRC cell proliferation and migration by acting as a cytoplasmic ceRNA for miR-942-5p, thereby increasing TET1 expression and contributing to tumor-suppressive epigenetic regulation.
Confidence score:

0.7486
Other information
Title:

Circ_0007919 exerts an anti-tumor role in colorectal cancer through targeting miR-942-5p/TET1 axis.

Journal: Pathology, research and practice
Published: 2022
PubMed ID: 34906917
Study type:

combined biological and clinical study
Data availability: GSE138589; GSE126093; GSE128446; The data used to support the findings of this study are available from the corresponding author upon request; doi:10.1016/j.prp.2021.153704
Code availability: -