| Expression pattern: |
UP |
| Associated gene: |
PABPC1, SETDB1 mRNA, SETDB1 |
| Associated microRNA: |
- |
| Biological function: |
Functions as an oncogene in BCa; promotes migration, invasion, lymph node metastasis, EMT, and gemcitabine resistance. |
| Molecular mechanism: |
circPTK2 directly binds the RBP PABPC1, forming a circRNA-protein complex that enhances PABPC1-mediated stabilization of SETDB1 mRNA, increases SETDB1 expression, activates SETDB1-mediated EMT and Wnt/beta-catenin-related effects, and promotes metastasis and gemcitabine resistance. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); Wnt/beta-catenin (promotes); mRNA stability (promotes); chemoresistance (promotes); drug resistance (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; IF (Immunofluorescence); Transfection; CCK8; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
circPTK2 is upregulated in BCa tissues, has diagnostic potential with AUC = 0.7154, is higher in high-grade and muscle-invasive BCa, and high circPTK2 expression is associated with worse prognosis. |
| Description: |
circPTK2 is an upregulated human circRNA derived from PTK2 in bladder cancer tissues and gemcitabine-resistant BCa cells. It promotes EMT-mediated migration, invasion, lymph node metastasis, and gemcitabine resistance by binding PABPC1 and enhancing PABPC1-dependent stabilization of SETDB1 mRNA, thereby increasing SETDB1 expression. |
| Confidence score: |
0.8924 |