| Expression pattern: |
UP |
| Associated gene: |
PLK1, Ago2 |
| Associated microRNA: |
miR-1224-3p |
| Biological function: |
promotes proliferation, migration and invasion; promotes in vivo tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circ-ZNF609 sponges miR-1224-3p to increase PLK1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Western Blot; CCK8; EdU Staining; Transwell Assay; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ-ZNF609 expression was interrelated to the poor prognosis of glioma patients |
| Description: |
circ-ZNF609 is up-regulated in glioma and promotes malignant phenotypes (proliferation, migration, invasion) and xenograft tumor growth. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-1224-3p to increase PLK1 expression, forming a circ-ZNF609/miR-1224-3p/PLK1 axis associated with poor prognosis. |
| Confidence score: |
0.8439 |