circRNA basic information
circBase ID: hsa_circ_0093398
Name: hsa_circ_PDSS1
Synonym: -
Host Gene: PDSS1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005611
MONDO name: bladder transitional cell carcinoma
Disease details: urothelial bladder cancer
Disease DO ID:
 4006
Disease MeSH ID:
 -
Disease NCIt ID:
 C39851
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; adjacent healthy tissues
Cell lines:

HT-1197; UMUC3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-16
Biological function: Promotes proliferation, migration and invasion of urothelial bladder cancer cells.
Molecular mechanism: circPDSS1 acts as an upstream inhibitor of miR-16, thereby promoting malignant behaviors of UBC cells.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay
Clinical significance:

Expression levels of circPDSS1 were increased with increase in clinical stages.
Description:

circPDSS1 is up-regulated in urothelial bladder cancer tissues and increases with higher clinical stage. In HT-1197 and UMUC3 cells, circPDSS1 overexpression suppresses miR-16 levels and promotes proliferation, migration, and invasion, while miR-16 overexpression counteracts these effects.
Confidence score:

0.5214
Other information
Title:

CircRNA circPDSS1 promotes bladder cancer by down-regulating miR-16.

Journal: Bioscience reports
Published: 2020
PubMed ID: 31868205
Study type:

combined biological and clinical study
Data availability: -
Code availability: -