| Expression pattern: |
UP |
| Associated gene: |
Bcl2, Ago2 |
| Associated microRNA: |
miR-3918 |
| Biological function: |
Promotes HCC cell proliferation, migration, invasion and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ-BIRC6 acts as a miRNA sponge for miR-3918, thereby promoting Bcl2 expression through the miR-3918/Bcl2 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); metastasis (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ-BIRC6 expression is associated with TNM stage, vascular invasion, shorter overall survival, and poor prognosis; circ-BIRC6 may serve as a biomarker and therapeutic target for HCC. |
| Description: |
circ-BIRC6 is up-regulated in HCC tissues and cell lines and high expression predicts poor overall survival. Functionally, circ-BIRC6 promotes HCC proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it acts as a sponge for miR-3918 to increase Bcl2 mRNA and protein expression through the circ-BIRC6/miR-3918/Bcl2 axis. |
| Confidence score: |
0.8066 |