circRNA basic information
circBase ID: hsa_circ_0008673
Name: -
Synonym: circ_0008673
Host Gene: -
Genomic location(hg19): chr17:41247862-41276132:-
Genomic location(hg38): chr17:43095845-43124115:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tumor tissues; paracancer tissues; tumor tissues
Cell lines:

MDA-MB-231; BT-549; MCF-7; T47D; MCF-10A; HUVECs
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: GINS4, CDK6, PCNA, Bcl2, Bax, Ki67
Associated microRNA: miR-578
Biological function: Promotes breast cancer cell growth, proliferation, migration, invasion, angiogenesis and tumor growth, and inhibits apoptosis.
Molecular mechanism: Hsa_circ_0008673 acts as a miR-578 sponge to positively regulate GINS4 expression, thereby promoting breast cancer progression through the hsa_circ_0008673/miR-578/GINS4 axis.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); angiogenesis (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

The hsa_circ_0008673/miR-578/GINS4 axis may be an important target therapy for breast cancer.
Description:

Hsa_circ_0008673 is up-regulated in breast cancer tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-578 to increase GINS4 expression, thereby promoting breast cancer cell proliferation, migration, invasion, angiogenesis and xenograft tumor growth while suppressing apoptosis. The hsa_circ_0008673/miR-578/GINS4 axis is proposed as a potential therapeutic target for breast cancer.
Confidence score:

0.8005
Other information
Title:

Hsa_circ_0008673 Promotes Breast Cancer Progression by MiR-578/GINS4 Axis.

Journal: Clinical breast cancer
Published: 2023
PubMed ID: 36628810
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request.
Code availability: -