circRNA basic information
circBase ID: hsa_circ_0001073
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr2:148653869-148657467:+
Genomic location(hg38): chr2:147896300-147899898:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tumors; adjacent normal tissues; LUAD tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Subtype-specific dysregulation in LUAD and potential diagnostic/subtyping biomarker for LUAD.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNase R Treatment; ROC Analysis
Clinical significance:

ROC analysis indicates diagnostic potential in LUAD (AUC 0.919).
Description:

hsa_circ_0001073 is specifically down-regulated in LUAD (not LUSC) and shows high diagnostic accuracy for LUAD by ROC analysis.
Confidence score:

0.5909
Other information
Title:

RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.

Journal: Molecular cancer
Published: 2019
PubMed ID: 31484581
Study type:

combined biological and clinical study
Data availability: All the data obtained and/or analyzed during the current study were available from the corresponding authors on reasonable request.
Code availability: -