| Expression pattern: |
UP |
| Associated gene: |
CCNT2, Ago2 |
| Associated microRNA: |
miR-507 |
| Biological function: |
Promotes HCC cell proliferation, migration, invasion, EMT, metastasis in vivo, and lenvatinib resistance. |
| Molecular mechanism: |
Acts as a competing endogenous RNA (miRNA sponge) for miR-507, relieving miR-507-mediated repression of CCNT2. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining |
| Clinical significance: |
High circ_0007386 expression is associated with worse prognosis and shorter overall survival in HCC patients; potential biomarker and therapeutic target. |
| Description: |
circ_0007386 (CRIM1-derived) is upregulated in HCC and mainly localized in the cytoplasm. It promotes proliferation, migration/invasion, EMT and in vivo tumor growth/metastasis by sponging miR-507 and derepressing CCNT2, and it also contributes to lenvatinib resistance; high expression predicts poor survival. |
| Confidence score: |
0.8832 |