| Expression pattern: |
DN |
| Associated gene: |
Pink1 |
| Associated microRNA: |
miR-421 |
| Biological function: |
circPAN3 ameliorates myocardial I/R injury, inhibits autophagy, alleviates cardiomyocyte apoptosis, reduces myocardial infarct size, and restores heart function in experimental models. |
| Molecular mechanism: |
circPAN3 acts as a ceRNA sponge for miR-421, thereby regulating Pink1 expression and suppressing Pink1-mediated autophagy and apoptosis in myocardial I/R injury. |
| Biological pathway or process: |
autophagy (inhibits); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; IF (Immunofluorescence); TUNEL; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
The circPAN3-miR-421-Pink1 axis may provide potential therapeutic targets for cardiovascular diseases and I/R injury. |
| Description: |
circPAN3 is downregulated in myocardial I/R injury and H/R-treated cardiomyocytes. Its overexpression protects against myocardial injury by sponging miR-421, regulating Pink1, and suppressing autophagy and apoptosis, suggesting the circPAN3/miR-421/Pink1 axis as a potential therapeutic target. |
| Confidence score: |
0.627 |