| Expression pattern: |
DN |
| Associated gene: |
SOX6, Ago2 |
| Associated microRNA: |
miR-1290 |
| Biological function: |
inhibits proliferation, invasion and migration and promotes apoptosis; suppresses tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0001946 sponges miR-1290 to de-repress SOX6 |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0001946 expression was significantly correlated with the tumor size, TNM stage, differentiation and lymph node metastasis of these tumors |
| Description: |
circ_0001946 is down-regulated in ESCC tissues and ESCC cell lines. Its overexpression suppresses proliferation, invasion and migration, promotes apoptosis, and inhibits xenograft tumor growth by sponging miR-1290 to relieve miR-1290-mediated repression of SOX6 (circ_0001946/miR-1290/SOX6 ceRNA axis). |
| Confidence score: |
0.8172 |