| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
circPVT1 is up-regulated in HNC cells and HNC cancer tissue, reduced after irradiation, and proposed as a potential biomarker to monitor radiotherapy effects in HNC patients. |
| Molecular mechanism: |
Predicted circRNA-miRNA interactions and radiation-induced changes in circPVT1 expression and cDNA pattern; the mechanistic role requires further study. |
| Biological pathway or process: |
ceRNA regulation (other); radioresistance (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
circPVT1 may be a potential biomarker to monitor radiotherapy effects in HNC patients; high expression was non-significantly associated with poor overall survival. |
| Description: |
hsa_circ_0001821/circPVT1, derived from the PVT1 locus, is significantly up-regulated in Detroit-562 HNC cells and HNC cancer tissue and is reduced after irradiation. The study predicts circPVT1-miRNA interactions and proposes circPVT1 as a potential biomarker for monitoring radiotherapy effects in HNC patients, although its association with poor overall survival was not statistically significant. |
| Confidence score: |
0.4685 |