circRNA basic information
circBase ID: hsa_circ_0009735
Name: hsa_circ_PGD
Synonym: circPGD
Host Gene: PGD
Genomic location(hg19): chr1:10477043-10480201:+
Genomic location(hg38): chr1:10416986-10420144:+
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastroscopic tissues / gastric tissues
Cell lines:

GES-1; HGC-27
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: p65, IL6, IL8, TNFalpha, vimentin, N-cadherin, MMP2, E-cadherin, Bcl-2, BAX, PCNA
Associated microRNA: -
Biological function: promotes proliferation and migration, enhances inflammatory response, and inhibits apoptosis in H. pylori-related gastric cancer cells
Molecular mechanism: H. pylori upregulates circPGD, which is associated with EMT-related protein changes, apoptosis-related Bcl-2/BAX changes, and increased p65 phosphorylation with elevated inflammatory cytokines
Biological pathway or process:

NF-kappaB (promotes); inflammation (promotes); apoptosis (inhibits); proliferation (promotes); migration (promotes); EMT (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; FISH / smFISH; Transfection; Transwell Assay; Colony Formation Assay; CCK8; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation
Clinical significance:

circPGD overexpression was associated with tumor size and lymph node metastasis; relevance as a possible diagnostic marker and therapeutic target
Description:

In H. pylori-related gastric cancer, circPGD (hsa_circ_0009735) is upregulated in infected cells and patient gastric tissues. Functionally, circPGD promotes proliferation, migration and EMT, enhances NF-kappaB-associated inflammatory responses, and inhibits apoptosis.
Confidence score:

0.5821
Other information
Title:

Helicobacter pylori upregulates circPGD and promotes development of gastric cancer.

Journal: Journal of cancer research and clinical oncology
Published: 2024
PubMed ID: 38407616
Study type:

combined biological and clinical study
Data availability: The online version contains supplementary material available at 10.1007/s00432-023-05537-w.
Code availability: -