| Expression pattern: |
UP |
| Associated gene: |
Rap2A, HEATR2 |
| Associated microRNA: |
miR-193a-5p |
| Biological function: |
Promotes ADM resistance, tumor growth, proliferation, migration and invasion, and inhibits apoptosis in breast cancer. |
| Molecular mechanism: |
circ_0001667 functions as a miRNA sponge for miR-193a-5p, thereby upregulating Rap2A expression through a ceRNA mechanism. |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
circ_0001667 was affirmed as a therapeutic biomarker in BC patients with ADM resistance. |
| Description: |
circ_0001667 is up-regulated in breast cancer, especially in ADM-resistant tissues and cells. It promotes ADM resistance and malignant progression by sponging miR-193a-5p to increase Rap2A expression, thereby enhancing proliferation, migration and invasion while reducing apoptosis. Knockdown of circ_0001667 suppresses tumor growth in a cell line-derived xenograft model and may improve ADM sensitivity. |
| Confidence score: |
0.8175 |